Regu-Mate Oral Solution 1000ml

Regu-Mate^® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Suppression of estrus will also facilitate management of prolonged estrus conditions. Suppression of estrus may be used to facilitate scheduled breeding during the physiological breeding season.

Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal in mares with ovarian follicles 20 mm or greater.

Suppression of estrus will facilitate:

● Attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season.

● Management of prolonged estrus conditions.

● Scheduled breeding during the physiological breeding season.

ORAL PROGESTIN

FOR USE IN ANIMALS ONLY

SOLUTION 0.22% (2.2 mg/mL)

Warning

DO NOT USE IN HORSES INTENDED FOR HUMAN CONSUMPTION.

Regu-Mate Solution Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications

Regu-Mate^® (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). Natural or synthetic gestagen therapy may exacerbate existing low-grade or “smoldering” uterine inflammation into a fulminating uterine infection in some instances.

Precautions

Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses manyfold greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia.

Dosage and Administration

While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. Remove cover from bottle dispensing tip and connect luer lock syringe (without needle). Draw out appropriate volume of Regu-Mate^® solution. (Note: Do not remove syringe while bottle is inverted as spillage may result.) Detach syringe and administer solution orally at the rate of 1 mL per 110 pounds body weight (0.044 mg/kg) once daily for 15 consecutive days. Administer solution directly on the base of the mare’s tongue or on the mare’s usual grain ration. Replace cover on bottle dispensing tip to prevent leakage. Excessive use of a syringe may cause the syringe to stick; therefore, replace syringe as necessary.

Keep this and all medication out of the reach of children.

How Supplied

Regu-Mate^® (altrenogest) Solution 0.22% (2.2 mg/mL).

Each mL contains 2.2 mg altrenogest in an oil solution.

Available in 1000 mL plastic bottles.

Manufactured for: Intervet Inc (d/b/a Merck Animal Health), Summit, NJ 07901

Made in France

NADA # 131-310, Approved by FDA