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Albon
Albon Oral Suspension
Albon Oral Suspension
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$39.99 USD
Regular price
$39.99
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$39.99
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SKU:496130 002
Prescription items are NON-RETURNABLE and NON REFUNDABLE
Albon 5% Oral Suspension
(sulfadimethoxine)
Albon is a low-dosage rapidly absorbed long-acting sulfonamide effective for the treatment of a wide range of bacterial infections commonly encountered in dogs and cats. For the treatment of sulfadimethoxine-sensitive bacterial infections in dogs and cats and bacterial enteritis associated with coccidiosis in dogs. Sulfadimethoxine is a white almost tasteless and odorless compound. Chemically it is N1-(2 6-dimethoxy-4-pyrimidinyl) sulfanilamide.
Item Specifications:
For Use:
Dogs and Cats
Manufacturer:
Pfizer
Dosage and Administration:
Use as Directed by Your Veterinarian
Limitations:
Sulfadimethoxine is not effective in viral or rickettsial infections and as with any antibacterial agent occasional failures in therapy may occur due to resistant microorganisms. The usual precautions in sulfonamide therapy should be observed.
Actions:
Sulfadimethoxine has been demonstrated clinically or in the laboratory to be effective against a variety of organisms such as streptococci klebsiella proteus shigella staphylococci escherichia and salmonella.1 2 These organisms have been demonstrated in respiratory genitourinary enteric and soft tissue infections of dogs and cats.
The systemic sulfonamides which include sulfadimethoxine are bacteriostatic agents. Sulfonamides competitively inhibit bacterial synthesis of folic acid (pterolyglutamic acid) from para-aminobenzoic acid. Mammalian cells are capable of utilizing folic acid in the presence of sulfonamides.
The tissue distribution of sulfadimethoxine as with all sulfonamides is a function of plasma levels degree of plasma protein binding and subsequent passive distribution in the tissues of the lipid-soluble un-ionized form. The relative amounts are determined by both its pKa and by the pH of each tissue. Therefore levels tend to be higher in less acid tissue and body fluids or those diseased tissues having high concentrations of leucocytes.2
In the dog sulfadimethoxine is not acetylated as in most other animals and it is excreted predominantly as the unchanged drug.3 Sulfadimethoxine has a relatively high solubility at the pH normally occurring in the kidney precluding the possibility of precipitation and crystalluria. Slow renal excretion results from a high degree of tubular reabsorption 4 and plasma protein binding is very high providing a blood reservoir of the drug. Thus sulfadimethoxine maintains higher blood levels than most other long-acting sulfonamides. Single comparatively low doses of Albon give rapid and sustained therapeutic blood levels.1
To assure successful sulfonamide therapy (1) the drug must be given early in the course of the disease and it must produce a high sulfonamide level in the body rapidly after administration (2) therapeutically effective sulfonamide levels must be maintained in the body throughout the treatment period (3) treatment should continue for a short period of time after the clinical signs have disappeared and (4) the causative organisms must be sensitive to this class of drugs.
Toxicity and Safety:
Data regarding acute and chronic toxicities of sulfadimethoxine indicate the drug is very safe. The LD50 in mice is greater than 2 g/kg of body weight when administered intraperitoneally and greater than 16 g/kg when administered orally. In dogs receiving massive single oral doses of 3.2 g/kg of body weight diarrhea was the only adverse effect observed. Dogs given 160 mg/kg of body weight orally daily for 13 weeks showed no signs of toxicity.
Warning:
Not for human use.
Precaution:
During treatment period make certain that animals maintain adequate water intake. If animals show no improvement within 2 or 3 days reevaluate your diagnosis.
Storage:
Store at controlled room temperature 15°-30°C (59°-86°C).
Sulfadimethoxine is not effective in viral or rickettsial infections and as with any antibacterial agent occasional failures in therapy may occur due to resistant microorganisms. The usual precautions in sulfonamide therapy should be observed.
Actions:
Sulfadimethoxine has been demonstrated clinically or in the laboratory to be effective against a variety of organisms such as streptococci klebsiella proteus shigella staphylococci escherichia and salmonella.1 2 These organisms have been demonstrated in respiratory genitourinary enteric and soft tissue infections of dogs and cats.
The systemic sulfonamides which include sulfadimethoxine are bacteriostatic agents. Sulfonamides competitively inhibit bacterial synthesis of folic acid (pterolyglutamic acid) from para-aminobenzoic acid. Mammalian cells are capable of utilizing folic acid in the presence of sulfonamides.
The tissue distribution of sulfadimethoxine as with all sulfonamides is a function of plasma levels degree of plasma protein binding and subsequent passive distribution in the tissues of the lipid-soluble un-ionized form. The relative amounts are determined by both its pKa and by the pH of each tissue. Therefore levels tend to be higher in less acid tissue and body fluids or those diseased tissues having high concentrations of leucocytes.2
In the dog sulfadimethoxine is not acetylated as in most other animals and it is excreted predominantly as the unchanged drug.3 Sulfadimethoxine has a relatively high solubility at the pH normally occurring in the kidney precluding the possibility of precipitation and crystalluria. Slow renal excretion results from a high degree of tubular reabsorption 4 and plasma protein binding is very high providing a blood reservoir of the drug. Thus sulfadimethoxine maintains higher blood levels than most other long-acting sulfonamides. Single comparatively low doses of Albon give rapid and sustained therapeutic blood levels.1
To assure successful sulfonamide therapy (1) the drug must be given early in the course of the disease and it must produce a high sulfonamide level in the body rapidly after administration (2) therapeutically effective sulfonamide levels must be maintained in the body throughout the treatment period (3) treatment should continue for a short period of time after the clinical signs have disappeared and (4) the causative organisms must be sensitive to this class of drugs.
Toxicity and Safety:
Data regarding acute and chronic toxicities of sulfadimethoxine indicate the drug is very safe. The LD50 in mice is greater than 2 g/kg of body weight when administered intraperitoneally and greater than 16 g/kg when administered orally. In dogs receiving massive single oral doses of 3.2 g/kg of body weight diarrhea was the only adverse effect observed. Dogs given 160 mg/kg of body weight orally daily for 13 weeks showed no signs of toxicity.
Warning:
Not for human use.
Precaution:
During treatment period make certain that animals maintain adequate water intake. If animals show no improvement within 2 or 3 days reevaluate your diagnosis.
Storage:
Store at controlled room temperature 15°-30°C (59°-86°C).
Model Numbers and UPCs
Model Numbers and UPCs
| Style | Item Number | UPC |
|---|---|---|
| 2oz | 496130 002 | 087219017913 |
| 16oz | 496130 016 | 087219017937 |
Returns
Returns
If you are not completely satisfied with an item, you may return it within 30 days from date received. Please note: item(s) must be new, unused, in original condition and box, including all parts, accessories, and packaging. Please DO NOT SHIP footwear (boots or shoes) in the manufacturer’s original box. Do not write or attach shipping labels to the manufacturer’s original box, you must ship all footwear in a protected box with the original box packed inside.
You must call us at 1.888.653.0026 to obtain a Return Authorization Number (RA#) and shipping instructions. Include a copy of the original invoice with your return and write your RA# visibly on the outside of the shipping package and on the packing slip.
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